• Product NameZK 756326
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySelective, non-peptide CCR8 chemokine receptor agonist (IC50?values are 1.8 and 2.6?μM for human and mouse receptors respectively). Displays no activity at CCR4, CXCR3, CXCR4 and CCR5 and shows > 28-fold selectivity over 26 other GPCRs (less selective at?α2A?and 5-HT receptors). Induces chemotaxis and inhibits Env-mediated (HIV) cell-cell fusion.
• Target NameCCR agonist
• CAS No. 874911-96-3
• Calculated MW 429.38
• Formulation C21H28N2O32HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CN(CCN1CCOCCO)CC2=CC(=CC=C2)OC3=CC=CC=C3.Cl.Cl
  Pathways:Immunology/Inflammation; Microbiology&virology
  Receptor:CCR8
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Haskell CA, et al. Mol Pharmacol. 2006 Jan;69(1):309-16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting