• Product NameJervine
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityJervine's biological activity is mediated via its interaction with the 7 pass trans membrane protein smoothened. Jervine binds with and inhibits smoothened, which is an integral part of the hedgehog signaling pathways. With smoothened inhibited, the GLI1 transcription cannot be activated and hedgehog target genes cannot be transcribed.
• Target NameHedgehog/Smoothened inhibitor
• CAS No. 469-59-0
• Calculated MW 425.61
• Formulation C27H39NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@H]1C[C@@H]2[C@H]([C@H]([C@]3(O2)CC[C@H]4[C@@H]5CC=C6C[C@H](CC[C@@]6([C@H]5C(=O)C4=C3C)C)O)C)NC1
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Hedgehog; Smoothened
  Boling pt:
  Melting pt:
  Solubility:Soluble in Chloroform
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chen JK, et al. Genes Dev. 2002 Nov 1; 16(21): 2743C2748.;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting