- Product Namephenylalanine
- Brief DescriptionInhibitors
- Purification98.00%
- Biological ActivityL-Phenylalanine is an antagonist at α2δ calcium channels with a Ki of 980 nM. IC50 Value: 980 nM Target: Calcium Channel L-Phenylalanine (LPA) is an electrically neutral amino acid, one of the twenty common amino acids used to biochemically form proteins. In the brain, L-phenylalanine is a competitive antagonist at the glycine binding site of NMDA receptor and at the glutamate binding site of AMPA receptor [2, 3]. At the glycine binding site of NMDA receptor L-phenylalanine has an apparent equilibrium dissociation constant (KB) of 573 ?M estimated by Schild regression which is considerably lower than brain L-phenylalanine concentration observed in untreated human phenylketonuria . L-Phenylalanine also inhibits neurotransmitter release at glutamatergic synapses in hippocampus and cortex with IC50 of 980 nM, a brain concentration seen in classical phenylketonuria, whereas D-phenylalanine has a significantly smaller effect
- Target NameCalcium Channel antagonist
- CAS No. 63-91-2
- Calculated MW 165.19
- Formulation C9H11NO2
- Storage 3 years -20˚C powder;2 years -80˚C in solvent;
