• Product NameTimosaponin BII
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityTimosaponin BII has anti-dementia activity and may be useful for the treatment of type 2 diabetes. Timosaponin BII has antioxidant activity, can inhibit the up-regulation of BACE1 and reduced the over-production of β-CTF and Aβ in rat retina, which was induced by FeCl?.
• Target NameBACE inhibitor; Beta Amyloid inhibitor; Others inhibitor
• CAS No. 136656-07-0
• Calculated MW 920.07
• Formulation C45H76O19
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C[C@H]1[C@@H]2[C@H](C[C@@H]3[C@@]2(CC[C@H]4[C@H]3CC[C@H]5[C@@]4(CCC(C5)OC6[C@@H](C(C([C@H](O6)CO)O)O)OC7C(C(C([C@H](O7)CO)O)O)O)C)C)OC1(CC[C@H](C)COC8C(C(C([C@H](O8)CO)O)O)O)O
  Pathways:Neuroscience; Others
  Receptor:BACE1; Aβ; β-CTF
  Boling pt:
  Melting pt:
  Solubility:Soluble in Pyridine, Methanol, Ethanol, etc.
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Huang JF, et al. BMC Complement Altern Med. 2012 Oct 22;12:189.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting