• Product NameIcaritin
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIcaritin has hormone regulation activity and cardiovascular function improvement activity. Icaritin has antiY activity, can induce S phase arrest and apoptosis, inhibit ENKL cell proliferation. Icaritin has anti-multiple myeloma activity, mainly mediated by inhibiting IL-6/JAK2/STAT3 signaling. Icaritin at low concentration (4 or 8 μmol/L) can promote rat chondrocyte proliferation and inhibit cell apoptosis, while the effect of Icaritin on rat chondrocyte at high concentration was reversed.
• Target NameJAK inhibitor; STAT inhibitor
• CAS No. 118525-40-9
• Calculated MW 368.38
• Formulation C21H20O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(=CCC1=C(C=C(C2=C1OC(=C(C2=O)O)C3=CC=C(C=C3)OC)O)O)C
  Pathways:Angiogenesis; JAK/STAT signaling; Chromatin/Epigenetic; Stem Cells
  Receptor:JAK2; STAT3
  Boling pt:
  Melting pt:
  Solubility:Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
  Appearance:Yellow powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Zhu S, et al. Oncotarget. 2015 Apr 30;6(12):10460-72.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting