• Product NameCucurbitacin B
• Brief DescriptionInhibitors
• Purification99.30%
• Biological ActivityCucurbitacin B has profound in vitro and in vivo antiproliferative effects against human pancreatic Y cells. It inhibited AKT signaling activation through up-regulation of PTEN. Cucurbitacin B is an effective inhibitor of HIF-1 and provide new perspectives into the mechanism of its antiY activity. Cucurbitacin B inhibits proliferation and induces apoptosis via STAT3 pathway inhibition in A549 lung Y cells.
• Target NameHIF inhibitor; PTEN inhibitor; STAT inhibitor
• CAS No. 6199-67-3
• Calculated MW 558.7
• Formulation C32H46O8
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(=O)OC(C)(C)/C=C/C(=O)[C@@](C)([C@H]1[C@@H](C[C@@]2([C@@]1(CC(=O)[C@@]3([C@H]2CC=C4[C@H]3C[C@@H](C(=O)C4(C)C)O)C)C)C)O)O
  Pathways:Angiogenesis; JAK/STAT signaling; Others; Chromatin/Epigenetic; Stem Cells
  Receptor:HIF-1; PTEN; STAT3
  Boling pt:
  Melting pt:
  Solubility:Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone, etc.
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Shang Y, et al. Eur Rev Med Pharmacol Sci. 2014;18(21):3297-303.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting