• Product NameAmentoflavone
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityAmentoflavone can interact with many other medications by being a potent inhibitor of CYP3A4 and CYP2C9, which are proteins used for drug metabolism in the body, is an inhibitor of human cathepsin B. It has antimalarial activity in trials significant affinities towards the delta-1, kappa opioid receptors (as an antagonist) and binds to benzodiazepine receptors. Amentoflavone may be a potential lead for a new type of anti-inflammatory agents having dual inhibitory activity of group II phospholipase A2 and cyclooxygenase. Amentoflavone and quercetin differentially exerted supression of PGE2 biosynthesis via downregulation of COX-2/iNOS expression.
• Target NameCOX inhibitor; Opioid Receptor antagonist; P450 antagonist; Phospholipase antagonist
• CAS No. 1617-53-4
• Calculated MW 538.46
• Formulation C30H18O10
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=CC(=CC=C1C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)C4=C(C=CC(=C4)C5=CC(=O)C6=C(C=C(C=C6O5)O)O)O)O
  Pathways:Endocrinology/Hormones; Immunology/Inflammation; Metabolism; GPCR/G Protein; Neuroscience
  Receptor:COX; COX-2; κ-opioid receptor; CYP2C9; CYP3A4; PLA2
  Boling pt:
  Melting pt:
  Solubility:Soluble in Chloroform, Dichloromethane, Ethyl Acetate, DMSO, Acetone
  Appearance:Yellow powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Sakthivel KM, et al. Int Immunopharmacol. 2013 Nov;17(3):907-16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting