• Product NameDemethylzeylasteral
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDemethylzeylasteral has strong immunosuppressive activity, can be used in the fields of organ transplantation and autoimmune disorders. The risk of elevated serum concentrations of estradiol due to the inhibition of estradiol glucuronidation by Demethylzeylasteral. Demethylzeylasteral increases both activation and inactivation time constants of Ca(2+) currents, can inhibit significantly the sperm acrosome reaction initiated by progesterone.
• Target NameUGT inhibitor
• CAS No. 107316-88-1
• Calculated MW 480.59
• Formulation C29H36O6
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer/ Immunology
  SMILES:C[C@]12CC[C@@](C[C@H]1[C@@]3(CC[C@]4(C5=CC(=C(C(=C5C(=O)C=C4[C@]3(CC2)C)C=O)O)O)C)C)(C)C(=O)O
  Pathways:Metabolism
  Receptor:UGT1A6; UGT2B7
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Liu SL et al. Eur J Drug Metab Pharmacokinet. 2014 Jun;39(2):99-102.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting