• Product NameChelerythrine chloride
• Brief DescriptionInhibitors
• Purification99.19%
• Biological ActivityCell-permeable inhibitor of protein kinase C (IC50?= 660 nM); competitive with respect to the phosphate acceptor and non-competitive with respect to ATP. Has a wide range of biological activities, including antiplatelet, anti-inflammatory, antibacterial and antitumor effects. Activates MAPK pathways, independent of PKC inhibition. Inhibits binding of BclXL?to Bak (IC50?= 1.5?μM) or Bad proteins and stimulates apoptosis.
• Target NamePKC inhibitor
• CAS No. 3895-92-9
• Calculated MW 383.83
• Formulation C21H18ClNO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[N+]1=C2C(=C3C=CC(=C(C3=C1)OC)OC)C=CC4=CC5=C(C=C42)OCO5
  Pathways:Cytoskeletal Signaling
  Receptor:PKC
  Boling pt:
  Melting pt:
  Solubility:Soluble to 10 mM in water and to 10 mM in DMSO
  Appearance:Orange powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Chan SL, et al. J Biol Chem. 2003 Jun 6;278(23):20453-6.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting