• Product NameML281
• Brief DescriptionInhibitors
• Purification99.71%
• Biological ActivityML281 is a potent and selective STK33 inhibitor with IC50 of 14 nM. ML281 showed a 550-fold selectivity over AurB and greater than 700-fold selectivity over PKA.
• Target NameSerine Protease inhibitor
• CAS No. 1404437-62-2
• Calculated MW 389.47
• Formulation C22H19N3O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:O=C(C1=CC=CS1)NC2=CC=C(C(C)C)C=C2C3=NC4=C(C=CC=C4)NC3=O
  Pathways:Proteases/Proteasome
  Receptor:STK33
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/Ml
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Spoonamore J et al. National Center for Biotechnology Information (US); 2010-2011 Dec 16.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting