• Product NamePF-4136309
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityINCB8761(PF-4136309) is a potent, Selective, and orally bioavailable CCR2 antagonist.
• Target NameCCR antagonist
• CAS No. 1341224-83-6
• Calculated MW 568.59
• Formulation C29H31F3N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CN(C[C@H]1NC2CCC(CC2)(C3=NC=C(C=C3)C4=NC=CC=N4)O)C(=O)CNC(=O)C5=CC(=CC=C5)C(F)(F)F
  Pathways:Immunology/Inflammation; Microbiology&virology
  Receptor:CCR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 32 mg/Ml
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Discovery of INCB8761/PF-4136309, a Potent, Selective, and Orally Bioavailable CCR2 Antagonist By Xue, Chu-Biao; Wang, Anlai; Han, Qi; Zhang, Yingxin; Cao, Ganfeng; Feng, Hao; Huang, Taisheng; Zheng, Changsheng; Xia, Michael; Zhang, Ke; et ACS Med. Chem. Lett., 2011, 2 (12), pp 913-918

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting