• Product NameLys05 trihydrochloride
• Brief DescriptionInhibitors
• Purification99.13%
• Biological ActivityLys05, or Lys01 trihydrochloride, is a potent, water soluble lysosomal autophagy inhibitor. Lys05 is a previously undescribed dimeric chloroquine which more potently accumulates in the lysosome and blocks autophagy compared with HCQ. Lys05 produced more potent antitumor activity as a single agent both in vitro and in vivo in multiple human cancer cell lines and xenograft models compared with HCQ. Lys05 is therefore a new lysosomal autophagy inhibitor that has potential to be developed further into a drug for cancer and other medical applications.
• Target Namelysosomal autophagy inhibitor
• CAS No. 1391426-24-6
• Calculated MW 549.75
• Formulation C23H26Cl5N5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Other
  SMILES:CN(CCNC1=CC=NC2=CC(Cl)=CC=C12)CCNC3=CC=NC4=CC(Cl)=CC=C34.[H]Cl.[H]Cl.[H]Cl
  Pathways:Autophagy
  Receptor:lysosomal autophagy(1205Lu); lysosomal autophagy(c8161); lysosomal autophagy(HT-29); lysosomal autophagy(LN229)
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6.4 mg/mL (Need Ultrasonic)
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.McAfee Q, et al. Proc Natl Acad Sci U S A. 2012 May 22;109(21):8253-8.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting