• Product NameVER-49009
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityVER-49009 is a pyrazole compound that inhibits Hsp90 with an IC50 value of 47 nM. IC50 value: 47 nM Target: Hsp90 VER-49009 produces a cellular antiproliferative GI50 value of 685 nM when tested against a human cancer cell line panel. Consistent with inhibition of Hsp90, VER-49009 induces the expression of Hsp27 and Hsp72 while reducing the client proteins C-RAF, B-RAF, survivin, and PRMT5, causing cell cycle arrest and apoptosis.
• Target NameHSP inhibitor
• CAS No. 558640-51-0
• Calculated MW 387.82
• Formulation C19H18ClN3O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CCNC(=O)C1=C(/C(=C/2\C=C(C(=CC2=O)O)Cl)/NN1)C3=CC=C(C=C3)OC
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP90
  Boling pt:
  Melting pt:
  Solubility:DMSO:10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Sharp SY, et al. Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues. Mol Cancer Ther. 2007 Apr;6(4):1198-211.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting