• Product NameEED226
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEED226 is a potent, selective, and orally bioavailable embryonic ectoderm development (EED) inhibitor with an IC50 of 22 nM.
• Target NameDNA Methyltransferase inhibitor; Histone Methyltransferase inhibitor
• CAS No. 2083627-02-3
• Calculated MW 369.399
• Formulation C17H15N5O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CS(=O)(=O)C1=CC=C(C=C1)C2=CN=C(N3C2=NN=C3)NCC4=CC=CO4
  Pathways:Chromatin/Epigenetic
  Receptor:EED; PRC2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 29 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Huang Y, et al. Discovery of First-in-Class, Potent, and Orally Bioavailable Embryonic Ectoderm Development (EED) Inhibitor with Robust Anticancer Efficacy. J Med Chem. 2017 Mar 23;60(6):2215-2226.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting