• Product NameHhAntag
• Brief DescriptionInhibitors
• Purification97.00%
• Biological ActivityHhAntag is a small molecule inhibitor of GLI1-mediated transcription, an essential down-stream element of the Hedgehog (Hh) pathway; antitumor agent.
• Target NameHedgehog/Smoothened inhibitor
• CAS No. 496794-70-8
• Calculated MW 450.923
• Formulation C24H23ClN4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(C)C1=CC2=C(C=C1)N=C(N2)C3=C(C=CC(=C3)NC(=O)C4=CC(=CC(=C4)OC)OC)Cl
  Pathways:GPCR/G Protein; Stem Cells
  Receptor:Gli
  Boling pt:
  Melting pt:
  Solubility:DMSO10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Actis, Marcelo; Connelly, Michele C.; Mayasundari, Anand et al. A structure-activity relationship study of small-molecule inhibitors of GLI1-mediated transcription. Biopolymers (2011), 95(1), 24-30.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting