• Product NameFIIN-3
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityFIIN-3 is an irreversible inhibitor of FGFR1-4 with IC50s of 13, 21, 31, and 35 nM, respectively.
• Target NameFGFR inhibitor
• CAS No. 1637735-84-2
• Calculated MW 691.614
• Formulation C34H36Cl2N8O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN1CCN(CC1)C2=CC=C(C=C2)NC3=CC(=NC=N3)N(CC4=CC=C(C=C4)NC(=O)C=C)C(=O)NC5=C(C(=CC(=C5Cl)OC)OC)Cl
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1; FGFR2; FGFR3; FGFR4
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Tan L et al. Development of covalent inhibitors that can overcome resistance to first-generation FGFR kinase inhibitors. Proc Natl Acad Sci U S A, 2014 Nov 11, 111(45):E4869-77

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting