• Product NamePCI-27483
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityPCI 27483 is a small molecule inhibitor of activated coagulation factor VIIa with antithrombotic effects in a baboon model of arterial thrombosis?It also inhibits the growth of BxPC3 xenografts by 42 and 85% at doses of 60 and 90 mg/kg, respectively.
• Target NameOthers inhibitor
• CAS No. 871266-63-6
• Calculated MW 596.571
• Formulation C26H24N6O9S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1=CC2=C(C=C1C(=N)N)NC(=C3C=C(C=C(C3=O)C4=C(C=CC(=C4)S(=O)(=O)N)O)CC(=O)NC(CC(=O)O)C(=O)O)N2
  Pathways:Others
  Receptor:Coagulation factor
  Boling pt:
  Melting pt:
  Solubility:DMSO:Soluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Gmez-Outes, A, et al. New parenteral anticoagulants in development. Ther. Adv. Cardiovasc. Disc. 5(1), 33-59 (2011).

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting