• Product NameCGS 27023A
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. Also, It is a nonpeptide matrix metalloprotease inhibitor which was undergoing phase I/II studies for the treatment of Solid tumours
• Target NameMMP inhibitor
• CAS No. 161314-82-5
• Calculated MW 429.916
• Formulation C18H24ClN3O5S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)[C@H](C(=O)NO)N(CC1=CN=CC=C1)S(=O)(=O)C2=CC=C(C=C2)OC.Cl
  Pathways:Proteases/Proteasome
  Receptor:MMP
  Boling pt:
  Melting pt:
  Solubility:DMSO: Soluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. MacPherson LJ, et al. Discovery of CGS 27023A, a non-peptidic, potent, and orally active stromelysin inhibitor that blocks cartilage degradation in rabbits. J Med Chem. 1997 Aug 1;40(16):2525-32.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting