• Product NameRO 46-8443
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityRO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition.
• Target NameEndothelin Receptor antagonist
• CAS No. 175556-12-4
• Calculated MW 609.694
• Formulation C31H35N3O8S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC(C=CC=C1)=C1OC2=C(OCC(O)CO)N=C(C3=CC=C(OC)C=C3)N=C2NS(C4=CC=C(C(C)(C)C)C=C4)(=O)=O
  Pathways:GPCR/G Protein
  Receptor:ET-B
  Boling pt:
  Melting pt:
  Solubility:DMSO:Soluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Guimar?es CL, Trentin PG, Rae GA. Endothelin ET(B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug;103 Suppl 48:340S-344S.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting