• Product NameFTIDC
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityFTIDC is a highly potent and selective allosteric antagonist of mGluR1 receptors and shows very weak potency against human and rat mGluR5 receptors. The inhibition of FTIDC for mGluR1 receptors is shown to be in noncompetitive manner and displays IC50 values of 5.8 and 3.1 nM for human and mouse mGluR1 expressed in CHO cells respectively.
• Target NameGluR antagonist
• CAS No. 873551-53-2
• Calculated MW 358.421
• Formulation C18H23FN6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(N=NN1C2=C(N=CC=C2)F)C3=CCN(CC3)C(=O)N(C)C(C)C
  Pathways:Neuroscience
  Receptor:mGluR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: Soluble
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ito S, et al. Discovery and biological profile of 4-(1-aryltriazol-4-yl)-tetrahydropyridines as an orally active new class of metabotropic glutamate receptor 1 antagonist. Bioorg Med Chem. 2008 Nov 15;16(22):9817-29.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting