• Product Name3-MATIDA
• Brief DescriptionInhibitors
• Purification98.00%
• Biological Activity3-MATIDA is a potent metabotropic glutamate receptor 1(mGluR-1) antagonist (IC50 = 6.3 μM at rat mGluR-1a). Displays 40-fold selectivity over other receptors: mGluR-5, mGluR-2, mGluR-4 (mGluR-4a) (IC50 > 300 μM), NMDA and GluR (AMPA) (IC50 = 250 μM). 3-MATIDA has been found to act as a neuroprotectant in cultured murine cortical cells and rat hippocampal slice cultures in vitro.
• Target NameGluR antagonist
• CAS No. 518357-51-2
• Calculated MW 215.223
• Formulation C8H9NO4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(SC(=C1)C(=O)O)C(C(=O)O)N
  Pathways:Neuroscience
  Receptor:mGluR1
  Boling pt:
  Melting pt:
  Solubility: 1eq. NaOH: 50 mM; DMSO:50 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Moroni, F., et al.The novel and systemically active metabotropic glutamate 1 (mGlu1) receptor antagonist 3-MATIDA reduces post-ischemic neuronal death.Neuropharmacology. 2002. Neuropharmacology. 42: 741-751.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting