• Product NameHSP70-IN-1
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityHSP70-IN-1 is a heat shock protein (HSP) inhibitor; inhibits the growth of Kasumi-1 cells with an IC50 of 2.3 μM.
• Target NameOthers inhibitor
• CAS No. 1268273-90-0
• Calculated MW 464.588
• Formulation C24H28N6O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CN(CC1)CCN1C2=NC=C(SC3=CC=CC(NC(CN)=O)=C3)C(OCC4=CC=CC=C4)=N2
  Pathways:Others
  Receptor:Kasumi-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10 mM
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Taldone T, et al. Heat shock protein 70 inhibitors. 2. 2,5'-thiodipyrimidines, 5-(phenylthio)pyrimidines, 2-(pyridin-3-ylthio)pyrimidines, and 3-(phenylthio)pyridines as reversible binders to an allosteric site on heat shock protein 70. J Med Chem. 2014 Feb 27;57(4):1208-24.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting