• Product NamePD-166866
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityPD166866 is a selective FGFR tyrosine kinase inhibitor with an IC50 of 52.4 nM .
• Target NameFGFR inhibitor
• CAS No. 192705-79-6
• Calculated MW 396.451
• Formulation C20H24N6O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=CC(=CC(=C3)OC)OC
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:FGFR1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 10.33 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Panek RL, et al. In vitro biological characterization and antiangiogenic effects of PD 166866, a selective inhibitor of the FGF-1 receptor tyrosine kinase. J Pharmacol Exp Ther. 1998 Jul;286(1):569-77.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting