• Product NameLW6
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityLW6 is a novel?HIF-1?inhibitor with an?IC50?of 4.4 μM.
• Target NameHIF inhibitor
• CAS No. 934593-90-5
• Calculated MW 435.52
• Formulation C26H29NO5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:COC(=O)C1=CC(=C(C=C1)O)NC(=O)COC2=CC=C(C=C2)C34CC5CC(C3)CC(C5)C4
  Pathways:Angiogenesis; Chromatin/Epigenetic
  Receptor:HIF-1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 33 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Naik R, et al. Synthesis and structure-activity relationship study of chemical probes as hypoxia induced factor-1α/malate dehydrogenase 2 inhibitors. J Med Chem. 2014 Nov 26;57(22):9522-38.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting