• Product NameCCG215022
• Brief DescriptionInhibitors
• Purification95.00%
• Biological ActivityCCG215022 is a G protein-coupled receptor kinases (GRKs) inhibitor with IC50s of 0.150.07 μM, 0.380.06 μM and 3.91 μM for GRK2, 5 and 1, respectively.
• Target NameGRK inhibitor; PKA inhibitor
• CAS No. 1813527-81-9
• Calculated MW 499.506
• Formulation C26H22FN7O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=C(C(NC(=O)N1)C2=CC(=C(C=C2)F)C(=O)NCC3=CC=CC=N3)C(=O)NC4=CC5=C(C=C4)NN=C5
  Pathways:GPCR/G Protein
  Receptor:GRK1; GRK2; GRK5; PKA
  Boling pt:
  Melting pt:
  Solubility:DMSO: 28 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Homan KT, et al. Crystal Structure of G Protein-coupled Receptor Kinase 5 in Complex with a Rationally DesignedInhibitor. J Biol Chem. 2015 Aug 21;290(34):20649-59.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting