• Product NameC29
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNovel inhibitor of TLR2/1 and TLR2/6 signaling induced by synthetic and bacterial TLR2 agonists in human HEK-TLR2 and THP-1 cells, but only TLR2/1 signaling in murine macrophages
• Target NameTLR inhibitor
• CAS No. 363600-92-4
• Calculated MW 285.299
• Formulation C16H15NO4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=C(C=CC=C1N/C=C\2/C=CC=C(C2=O)OC)C(=O)O
  Pathways:Immunology/Inflammation
  Receptor:TLR2/1; TLR2/6
  Boling pt:
  Melting pt:
  Solubility:DMSO: 30 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Pragnesh Mistry,Inhibition of TLR2 signaling by small molecule inhibitors targeting a novel putative pocket within the TLR2 TIR domain (INM9P.448). J Immunol May 1, 2014, 192 (1 Supplement) 189.1;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting