• Product NameSEA-0400
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySEA0400 is a selective inhibitor of the Na+/Ca2+?exchanger (IC50s = 5, 8.3, and 33 nM for inhibiting Na+-dependent Ca2+?uptake in rat astrocyte, microglia, and cortical neuron cell lines, respectively).?It is reported to prevent dopaminergic neurotoxicity in an MPTP mouse model of Parkinson's disease and to attenuate reperfusion injury in both?in vitro?and?in vivo?cerebral ischemic models.
• Target NameCalcium Channel inhibitor
• CAS No. 223104-29-8
• Calculated MW 371.384
• Formulation C21H19F2NO3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:NC1=CC(OCC)=CC=C1OC2=CC=C(OCC3=CC(F)=CC=C3F)C=C2
  Pathways:Membrane transporter/Ion channel
  Receptor:NCX
  Boling pt:
  Melting pt:
  Solubility:DMSO>18.6mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Matsuda, T., et al. SEA0400, a novel and selective inhibitor of the Na+-Ca2+ exchanger, attenuates reperfusion injury in the in vitro and in vivo cerebral ischemic models. J.Pharmacol.Exp.Ther. 2001, 298(1), 249-256.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting