• Product NameGSK269962A
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityGSK269962 is a selective ROCK(Rho-associated protein kinase) inhibitor with IC50 values of 1.6 and 4 nM for ROCK1 and ROCK2, respectively.
• Target NameROCK inhibitor; S6 Kinase inhibitor
• CAS No. 850664-21-0
• Calculated MW 570.61
• Formulation C29H30N8O5
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CCN1C2=CC(=NC=C2N=C1C3=NON=C3N)OC4=CC=CC(=C4)NC(=O)C5=CC=C(C=C5)OCCN6CCOCC6
  Pathways:Cell Cycle/Checkpoint; PI3K/Akt/mTOR signaling; Stem Cells
  Receptor:MSK1; ROCK1; ROCK2; RSK1
  Boling pt:
  Melting pt:
  Solubility:DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Doe C, et al. Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. J Pharmacol Exp Ther. 2007 Jan;320(1):89-98. Epub 2006 Oct 3.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting