• Product NameDasotraline hydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityDasotraline hydrochloride (SEP-225289 hydrochloride) is a triple reuptake inhibitor? that blocks dopamine, norepinephrine, and serotonin transporters with IC50 values of 4, 6, and 11 nM, respectively.
• Target Name5-HT Receptor inhibitor; Dopamine Receptor inhibitor; Norepinephrine inhibitor
• CAS No. 675126-08-6
• Calculated MW 328.66
• Formulation C16H16Cl3N
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1C[C@H](C2=CC=CC=C2[C@@H]1C3=CC(=C(C=C3)Cl)Cl)N.Cl
  Pathways:GPCR/G Protein; Neuroscience
  Receptor:5-HT; Dopamine; Norepinephrine (NE)
  Boling pt:
  Melting pt:
  Solubility:Soluble in water
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Guiard BP, et al. Characterization of the electrophysiological properties of triple reuptake inhibitors on monoaminergic neurons. Int J Neuropsychopharmacol. 2011 Mar;14(2):211-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting