• Product NameTRC 051384
• Brief DescriptionInhibitors
• Purification92.66%
• Biological ActivityInducer of heat shock protein Hsp70; reduces stroke-associated neuronal injury and increases survival in a rat model of transient ischemic stroke. Activates heat shock factor-1 and results in elevated chaperone and anti-inflammatory activity. Enhances Hsp72 expression in neurons and glial cells.
• Target NameHSP inducer
• CAS No. 867164-40-7
• Calculated MW 465.54
• Formulation C25H31N5O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1COCCN1CCNC(=O)NC2=CC=C(C=C2)C(=O)/C=C/C3=NC(=CC=C3)N4CCOCC4
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP70
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Mohanan et al. Delayed intervention in experimental stroke with TRC051384--a small molecule HSP70 inducer. 2011, Neuropharmacology. 60 991.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting