• Product NameApilimod mesylate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityApilimod(STA 5326) mesylate is a potent?IL-12/IL-23?inhibitor, IL-12 production in cultures of IFN-r/LPSCstimulated human PBMCs is strongly inhibited by STA-5326 with an?IC50?of 10 nM.
• Target NameIL Receptor inhibitor
• CAS No. 870087-36-8
• Calculated MW 610.701
• Formulation C25H34N6O8S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology system
  SMILES:CC1=CC=CC(=C1)/C=N/NC2=NC(=NC(=C2)N3CCOCC3)OCCC4=CC=CC=N4.CS(=O)(=O)O.CS(=O)(=O)O
  Pathways:Immunology/Inflammation
  Receptor:IL-12; IL-23
  Boling pt:
  Melting pt:
  Solubility:DMSO:10 mM/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Wada Y, et al. Selective abrogation of Th1 response by STA-5326, a potent IL-12/IL-23 inhibitor. Blood. 2007 Feb 1;109(3):1156-64.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting