• Product NameML240
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityML240 is a selective, ATP-competitive p97 inhibitor with IC50 values of 100 nM. target : p97 IC 50: 100 nM In vitro: ML240 potently stimulated accumulation of LC3-II within minutes, inhibited cancer cell growth, and rapidly mobilized the executioner caspases 3 and 7. The behavior of ML240 suggests that disruption of the protein homeostasis function of p97 leads to more rapid activation of apoptosis than is observed with a proteasome inhibitor. Meanwhile ML240 has broad antiproliferative activity toward the NCI-60 panel of cancer cell lines.
• Target Namep97 inhibitor
• CAS No. 1346527-98-7
• Calculated MW 396.44
• Formulation C23H20N6O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC=CC2=C1N=C(N=C2NCC3=CC=CC=C3)N4C5=CC=CC=C5N=C4N
  Pathways:Ubiquitination
  Receptor:P97
  Boling pt:
  Melting pt:
  Solubility:DMSO: 16.5 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tsui-Fen Chou et al. Specific Inhibition of p97/VCP ATPase and Kinetic Analysis Demonstrate Interaction between D1 and D2 ATPase domains.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting