• Product NameGSK583
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityGSK583 is a highly potent and selective inhibitor of RIP2 kinase with an IC50 of 5 nM.
• Target NameTNF inhibitor
• CAS No. 1346547-00-9
• Calculated MW 398.456
• Formulation C20H31FN4O2S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC(C)(C)S(=O)(=O)C1=CC2=C(C=CN=C2C=C1)NC3=NNC4=C3C=C(C=C4)F
  Pathways:Apoptosis
  Receptor:RIP1; RIP3
  Boling pt:
  Melting pt:
  Solubility:DMSO: 37 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Haile PA,et al. The Identification and Pharmacological Characterization of 6-(tert-Butylsulfonyl)-N-(5-fluoro-1H-indazol-3-yl)quinolin-4-amine (GSK583), a Highly Potent and Selective Inhibitor of RIP2 Kinase.J Med Chem. 2016 May 26;59(10):4867-80.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting