• Product NameIMR-1A
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityIMR-1A is the metabolite of IMR-1. IMR-1 is a novel class of Notch inhibitors targeting the transcriptional activation with IC50 of 6 μmol/L.
• Target NameGamma-secretase inhibitor
• CAS No. 331862-41-0
• Calculated MW 325.36
• Formulation C13H11NO5S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=C(C=CC(=C1)/C=C/2\C(=O)NC(=S)S2)OCC(=O)O
  Pathways:Neuroscience; Proteases/Proteasome; Stem Cells
  Receptor:Notch
  Boling pt:
  Melting pt:
  Solubility:DMSO: 31 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Astudillo L,et al. The Small Molecule IMR-1 Inhibits the Notch Transcriptional Activation Complex to Suppress Tumorigenesis. Cancer Res. 2016 Jun 15;76(12):3593-603.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting