• Product NameCC-122
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityCC-122 is an orally available pleiotropic pathway modulator with potential antineoplastic activity. CC-122 mimics an interferon response and has antitumor activity in DLBCL CC-122 binds Cereblon (CRBN) and promotes degradation of Aiolos and Ikaros in diffuse large B-cell lymphoma (DLBCL) and T cells in vitro, in vivo, and in patients, resulting in both cell autonomous as well as immunostimulatory effects.
• Target NameOthers
• CAS No. 1015474-32-4
• Calculated MW 286.11
• Formulation C14H14N4O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:CC1=NC2=C(C(=CC=C2)N)C(=O)N1C3CCC(=O)NC3=O
  Pathways:Others
  Receptor:Others
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:Brown powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Patrick R. Hagner, et al. Blood. 2015 Aug 6; 126(6): 779C789.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting