• Product NameEnsartinib
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityEnsartinib, also known as X-396, is an orally available small molecule inhibitor of the receptor tyrosine kinase anaplastic lymphoma kinase (ALK) with potential antineoplastic activity. Upon oral administration, X-396 binds to and inhibits ALK kinase, ALK fusion proteins and ALK point mutation variants. Inhibition of ALK leads to the disruption of ALK-mediated signaling and eventually inhibits tumor cell growth in ALK-expressing tumor cells. ALK belongs to the insulin receptor superfamily and plays an important role in nervous system development.
• Target NameALK inhibitor
• CAS No. 1365267-27-1
• Calculated MW 547.41
• Formulation C25H25Cl2FN5O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C[C@H](C1=C(C=CC(=C1Cl)F)Cl)OC2=CC(=NN=C2N)C(=O)NC3=CC=C(C=C3)C(=O)N4CCN(CC4)C
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:ALK
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Caccese M, et al. Expert Opin Pharmacother. 2016 Dec;17(17):2253-2266.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting