• Product NameML364
• Brief DescriptionInhibitors
• Purification99.35%
• Biological ActivityML364 is an USP2 inhibitor extracted from patent WO 2016134026 A1, compound example 10G.
• Target NameDUB inhibitor
• CAS No. 1991986-30-1
• Calculated MW 517.54
• Formulation C24H18F2N2O2S2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:O=C(NC1=NC(C2=CC=CC=C2)=CS1)C3=CC=C(C(F)(F)F)C=C3NS(=O)(C4=CC=C(C)C=C4)=O
  Pathways:Ubiquitination
  Receptor:USP2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 33 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Davis MI,et al. Small Molecule Inhibition of the Ubiquitin-specific Protease USP2 Accelerates cyclin D1 Degradation and Leads to Cell Cycle Arrest in Colorectal Cancer and Mantle Cell Lymphoma Models. J Biol Chem. 2016 Nov 18;291(47):24628-24640. Epub 2016 Sep 28.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting