• Product NameNIH-12848
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityNIH-12848 is a putative phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) inhibitor with an IC50 of 1 μM.
• Target NamePI3K inhibitor
• CAS No. 959551-10-1
• Calculated MW 385.41
• Formulation C20H14F3N3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Respiratory system/
  SMILES:FC(F)(F)C(C=CC=C1)=C1C2=NC3=CC=CC=C3C(NCC4=CC=CS4)=N2
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PI5P4Kγ
  Boling pt:
  Melting pt:
  Solubility:DMSO: 28 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Clarke JH,et al. The function of phosphatidylinositol 5-phosphate 4-kinase γ (PI5P4Kγ) explored using a specific inhibitor that targets the PI5P-binding site. Biochem J. 2015 Mar 1;466(2):359-67.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting