• Product NameNSC 86429
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivitySU-4312, also known as DMBI, is a potent and selective inhibitor of VEGFR and PDGFR tyrosine kinases (IC50 values are 0.8 and 19.4 μM respectively). SU4312 unexpectedly protects against MPP(+) -induced neurotoxicity via selective and direct inhibition of neuronal NOS.
• Target NamePDGFR; VEGFR inhibitor
• CAS No. 5812-7-7
• Calculated MW 264.328
• Formulation C17H16N2O
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CN(C)C1=CC=C(C=C1)/C=C\2/C3=CC=CC=C3NC2=O
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:PDGFR; VEGFR
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Li Y, et al. Vascular Endothelial Growth Factor-A (VEGF-A) Mediates Activin A-Induced Human Trophoblast Endothelial-Like Tube Formation. Endocrinology. 2015 Nov;156(11):4257-68.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting