• Product NameSematilide (CK-1752)
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySematilide, also known as CK-1752, is a class III antiarrhythmic. It is a selective delayed rectifier K+ current (IKr) channel blocker. It inhibits rapidly activating Ik in guinea pig atrial myocytes, resulting in the prolongation of action potential duration and refractoriness.
• Target NameOthers inhibitor
• CAS No. 101526-62-9
• Calculated MW 349.874
• Formulation C14H24ClN3O3S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cardiovascular system
  SMILES:CCN(CC)CCNC(=O)C1=CC=C(C=C1)NS(=O)(=O)C.Cl
  Pathways:Others
  Receptor:K+ current (IKr) channel
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Yoshida H,et al. Comparison of the in vivo electrophysiological and proarrhythmic effects of amiodarone with those of a selective class III drug, sematilide, using a canine chronic atrioventricular block model. Circ J. 2002 Aug;66(8):758-62.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting