• Product NameCompound 401
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityCompound 401 is a synthetic inhibitor of DNA-PK (IC50 = 0.28 μM) that also targets mTOR but not PI3K.
• Target NameDNA-PK inhibitor
• CAS No. 168425-64-7
• Calculated MW 281.31
• Formulation C16N15H3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1COCCN1C2=CC(=O)N3C=CC4=CC=CC=C4C3=N2
  Pathways:DNA Damage/DNA Repair; PI3K/Akt/mTOR signaling
  Receptor:DNA-PK
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Ballou LM,et al. Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl)pyrimido[2,1-alpha]isoquinolin-4-one. J Biol Chem. 2007 Aug 17;282(33):24463-70. Epub 2007 Jun 11.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting