• Product NameNSC23005 Sodium
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityNSC23005 sodium is a novel and effective p18 inhibitor (ED50=5.21 nM) in promoting Hematopoietic stem cells (HSCs) expansion in both murine and human models. ED50 & Target: 5.21 nM (p18INK4C)
• Target NameCDK inhibitor
• CAS No. 1796596-46-7
• Calculated MW 305.324
• Formulation C13H16NNaO4S
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:C1CCC(CC1)NS(=O)(=O)C2=CC=C(C=C2)C(=O)[O-].[Na+]
  Pathways:Cell Cycle/Checkpoint
  Receptor:p18INK4C
  Boling pt:
  Melting pt:
  Solubility:DMSO: 6.4 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Xie XQ, et al. Discovery of novel INK4C small-molecule inhibitors to promote human and murine hematopoietic stem cell ex vivo expansion. Sci Rep. 2015 Dec 18;5:18115.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting