• Product NameML346
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityML346 is a novel activator of Hsp70 with EC50 of 4600 nM in HeLa cell toxicity assay.
• Target NameHSP inhibitor
• CAS No. 100872-83-1
• Calculated MW 272.26
• Formulation C14H12N2O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:COC1=CC=C(C=C1)C=CC=C2C(=O)NC(=O)NC2=O
  Pathways:Cytoskeletal Signaling; Metabolism
  Receptor:HSP70
  Boling pt:
  Melting pt:
  Solubility:DMSO: 29 mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Calamini B,et al. ML346: A Novel Modulator of Proteostasis for Protein Conformational Diseases. National Center for Biotechnology Information (US); 2010-2012 Dec 17.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting