• Product NameMGL3196
• Brief DescriptionInhibitors
• Purification99.50%
• Biological ActivityMGL-3196 is a highly selective thyroid hormone receptor β (THR-β) agonist with an EC50 value of 0.21 μM.
• Target NameThyroid hormone receptor(THR) agonist
• CAS No. 920509-32-6
• Calculated MW 435.22
• Formulation C17H12CL2N6O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:cardiovascular system
  SMILES:CC(C)C1=CC(=NNC1=O)OC2=C(C=C(C=C2Cl)N3C(=O)NC(=O)C(=N3)C#N)Cl
  Pathways:Endocrinology/Hormones
  Receptor:THR-β
  Boling pt:
  Melting pt:
  Solubility:DMSO: 31mg/mL
  Appearance:
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kelly MJ, et al. Discovery of 2-[3,5-dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β agonist in clinical trials for the treatment of dyslipidemia. J Med Chem. 2014 May 22;57(10):3912-23.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting