• Product NameCutamesine dihydrochloride
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivitySelective?1 receptor agonist (IC50?= 17.4 nM). Exhibits selectivity for?1 over?2 receptors. Inhibits angiotensin II-induced cardiomyocyte hypertrophy?in vitro?and attenuates myocardial hypertrophy?in vivo. Enhances brain plasticity and sensorimotor function in a rat model of experimental stroke.
• Target NameSigma receptor agonist
• CAS No. 165377-44-6
• Calculated MW 441.43
• Formulation C23H32N2O22HCl
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:COC1=C(C=C(C=C1)CCN2CCN(CC2)CCCC3=CC=CC=C3)OC.Cl.Cl
  Pathways:GPCR/G Protein
  Receptor:σ1
  Boling pt:
  Melting pt:
  Solubility:Water: 100 mM; DMSO: 20 Mm
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Tagashira H, et al. Biochim Biophys Acta. 2013, 1830(4):3082-94.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting