• Product NameBFH772
• Brief DescriptionInhibitors
• Purification97.71%
• Biological ActivityBFH772, a structure analogue of BAW2881, is a potent and selective VEGF inhibitor. BFH772 is highly effective at targeting VEGFR2 kinase with an IC50 value of 3 nM. BFH772 inhibits the ligand induced autophosphorylation of RET, PDGFR, and KIT kinases, with IC50 values ranging between 30 and 160 nM.
• Target NameVEGFR inhibitor
• CAS No. 890128-81-1
• Calculated MW 439.39
• Formulation C23H16F3N3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Immunology
  SMILES:C1=CC(=CC(=C1)NC(=O)C2=CC=CC3=C2C=CC(=C3)OC4=NC=NC(=C4)CO)C(F)(F)F
  Pathways:Angiogenesis; Tyrosine Kinase/Adaptors
  Receptor:VEGFR2
  Boling pt:
  Melting pt:
  Solubility:DMSO: 87 mg/mL (198.0 mM); Ethanol: 87 mg/mL (198.0 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bold G, et al. J Med Chem. 2016, 59(1):132-46.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting