• Product NameLicochalcone A
• Brief DescriptionInhibitors
• Purification98.00%
• Biological ActivityLicochalcone A exhibits potent antimalarial activity via and might be developed into a new antimalarial drug. Licochalcone A had anti-tumor activity in all cell lines tested and enhanced the effect of paclitaxel and vinblastine chemotherapy. Licochalcone A induced apoptosis in MCF-7 and HL-60 cell lines, as demonstrated by cleavage of PARP, the substrate of ICE-like proteases. Licochalcone A exhibits a strong antileishmanial activity ,that appropriate substituted chalcones might be a new class of antileishmanial drugs.
• Target NameCaspase inhibitor
• CAS No. 58749-22-7
• Calculated MW 338.4
• Formulation C21H22O4
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer/ Endocrine system
  SMILES:CC(C)(C=C)C1=C(C=C(C(=C1)/C=C/C(=O)C2=CC=C(C=C2)O)OC)O
  Pathways:Apoptosis; Proteases/Proteasome
  Receptor:Caspase-3
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO, Chloroform
  Appearance:Yellow powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Kim SH, et al. Exp Biol Med (Maywood). 2015 Jan;240(1):26-33.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting