• Product NameSodium?Dichloroacetate
• Brief DescriptionInhibitors
• Purification99.00%
• Biological ActivityInhibitor of mitochondrial pyruvate dehydrogenase kinase (PDK). Shifts pyruvate metabolism from glycolysis and lactate production to glucose oxidation in the mitochondria. Induces mitochondrial-dependent apoptosis and reverses the inhibition/downregulation of KV1.5 channels in Y but not normal cells. Decreases tumor growth?in vitro?and?in vivo.
• Target NamePDK inhibitor
• CAS No. 2156-56-1
• Calculated MW 150.92
• Formulation C2HCl2NaO2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Metabolism
  SMILES:C(C(=O)[O-])(Cl)Cl.[Na+]
  Pathways:PI3K/Akt/mTOR signaling
  Receptor:PDK
  Boling pt:
  Melting pt:
  Solubility:Soluble in DMSO
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Bonnet S, et al. Y Cell. 2007 Jan;11(1):37-51.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting