• Product NameVU 0357017 hydrochloride
• Brief DescriptionInhibitors
• Purification99.13%
• Biological ActivityVU 0357017 hydrochloride is a highly selective M1 agonists that appear to act at an allosteric site to activate the receptor (EC50 = 477 172 Nm; Pec50 = 6.37 0.15).
• Target NameAChR inhibitor
• CAS No. 1135242-13-5
• Calculated MW 369.89
• Formulation C18H28ClN3O3
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Others
  SMILES:CC1=CC=CC=C1C(NCCNC2CCN(C(OCC)=O)CC2)=O
  Pathways:Neuroscience
  Receptor:M1 mAChR
  Boling pt:
  Melting pt:
  Solubility:DMSO: 33 mg/mL
  Appearance:White powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1.Digby GJ, et al. ACS Chem Neurosci. 2012 Dec 19;3(12):1025-36.

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting