• Product NameCobimetinib
• Brief DescriptionInhibitors
• Purification99.60%
• Biological ActivityCobimetinib is a selective inhibitor of mitogen-activated protein kinase kinase (MEK) with IC50 value of 0.9 nM
• Target NameMEK inhibitor
• CAS No. 934660-93-2
• Calculated MW 531.32
• Formulation C21H21F3IN3O2
• Storage 3 years -20˚C powder;2 years -80˚C in solvent;

• Research Area:Cancer
  SMILES:C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O
  Pathways:MAPK
  Receptor:MEK1
  Boling pt:
  Melting pt:
  Solubility:DMSO: 100 mg/mL (188.21 mM); Ethanol: 47 mg/mL warming (88.46 mM)
  Appearance:Powder
  Remark:For obtaining a higher solubility , please warm the tube at 37 ˚C and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20 ˚C for several month.

1. Hoeflich KP, et al. Y Res. 2012, 72(1), 210-219.;Baudy AR, et al. EJNMMI Res. 2012, 2(1), 22.;

• Flow Cytometry (FCM) General Protocol
• Immunofluorescence(IC)
• Immunohistochemistry(Polymer)
• Western Blotting